Tandem mass spectrometry is a powerful tool in proteomics. By ionizing peptides and then fragmenting those ions into smaller product ions, researchers can determine the biomolecules’ amino acid ...

Electron ionization (EI) is a hard ionization method that is typically used with gas chromatography-mass spectrometry (GC-MS). The mass spectral fragmentation patterns generated by EI are used for ...

What will you learn on this course? This course is an introduction to mass spectral interpretation, aimed at presenting the fundamental tools and rules when examining high quality full-scan GC-MS data ...

The process of protein identification typically begins with a bottom-up approach, where proteins are enzymatically digested—most commonly with trypsin—into smaller peptides. These peptides are ...

Sensitivity is a fundamental performance characteristic of a mass spectrometer. Increasingly higher sensitivities are in constant demand in order to characterize and quantify analytes that are at an ...

Its true value depends not on the number of detected features but on the reliability of metabolite identification and pathway analysis. Despite well-established guidelines, annotation and definitive ...