Pasca Lab specializes in growing three-dimensional organoid models from reprogrammed stem cells, which capture molecular changes during fetal brain-like development. Because the human brain cannot be ...

Geneticists have sought to understand the impact of genetic mutations, and what drives and maintains changes in DNA. Researchers have now reconstructed the evolution of a set of genes, and the ...

Hear the latest science news, with Shamini Bundell and Benjamin Thompson. Your browser does not support the audio element. A long-standing doctrine in evolution is ...

The DNA mutations that drive evolution are generally thought to be fairly random, but a new study suggests there’s some order to the chaos. Comparing the genomes of hundreds of plants grown in a lab, ...

Mutation: it’s the raw material for evolution. That makes knowing the rate at which it occurs crucial to the study of evolutionary biology. Mutation rate figures into all kinds of calculations. For ...

A woman in her late 20s presented with a 5-year history of progressive fatigue and generalised weakness. Examination revealed signs of premature ageing, anaemia, neuropathy and hepatosplenomegaly.

This produces point mutations in the DNA, which are mostly harmless but can sometimes lead to genetic disorders. In the new study, the Surrey researchers discovered that some of these modifications ...

Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...

SOX17 mutations are linked to severe pulmonary arterial hypertension often diagnosed in childhood, though some develop the ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere with neurons' ...

Banana and plantain are among the world's major food crops, and considered as the poor man's fruit crop in tropical and subtropical countries. The world's total banana and plantain production ranks ...