In translation, aa-tRNA, EF-Tu and GTP form a ternary complex that binds to the ribosome, allowing codon-anticodon pairing in the 30S ribosomal subunit. Cognate codon recognition triggers fast GTP ...
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Discovery of a tRNA methyltransferase with an unusual domain architecture and functional features
All living organisms encode the amino acid sequences of proteins as nucleotide sequences (genetic information) in their genomic DNA. The genetic information is transcribed and subsequently translated ...
RNA or ribonucleic acid is a polymer of nucleotides that is made up of a ribose sugar, a phosphate, and bases such as adenine, guanine, cytosine, and uracil. It plays a crucial role in gene expression ...
Between 10 to 15% of all genetic diseases have the same underlying cause: a nonsense mutation. 1 This type of mutation results from a stop codon in the middle of a gene sequence, which terminates ...
NSABP B-59/GBG 96-GeparDouze: A randomized double-blind phase III clinical trial of neoadjuvant chemotherapy (NAC) with atezolizumab or placebo in patients (pts) with triple-negative breast cancer ...
The study's main contributors include (L-R) graduate student Joshua Shaffer, professor Upasna Sharma, and postdoc Alka Gupta. (Photo by Carolyn Lagattuta) The pioneering research of UC Santa Cruz’s ...
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