Could measuring proteins in the blood help pinpoint which genes underlie certain GWAS signals? By combining plasma proteomics data with genetic analyses, scientists led by Keenan Walker at the ...
Two new ApoE variants turned up in American populations. Protective variant W276C discourages ApoE from oligomerizing. Risk variant R189C promotes its lipidation. Lipidated ApoE4 disrupts microglial ...
Member reports the following financial or other potential conflicts of interest: Received fundings from AC Immune, AstraZeneca, H. Lundbeck A/S, Pfizer, Roche, Michael J Fox Foundation ...
Kenneth Chen, M.D., Ph.D. Stanford University School of Medicine Contact Information Kenneth Chen, M.D., Ph.D. United States ...
Billions of years have passed since mitochondria left their freewheeling proteobacterial days behind them, but the nucleic acids within these endosymbiotic organelles still retain features of their ...
How does APOE4 aggravate the risk of Alzheimer’s disease, and how does APOE2 protect against it? Some scientists are turning to the plasma proteome for clues. In the May 15 Nature Aging, a group led ...
Contact Information Faisal Naqvi Ireland Professional Information ...
Proteomic panels come up short in the search for a plasma biomarker of Lewy bodies. AI may help.
Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly ...
This database is a repository of normal genetic variability, designed to be a tool for researchers who study neurodegenerative disease. It contains whole-exome sequencing results from nearly 500 ...
It has been clear for a while that anti-amyloid antibodies can sweep plaque from the brain, but until now the question of whether this slows cognitive decline has remained hotly contended. Despite ...
On donanemab, younger people with fewer tangles benefitted the most. On lecanemab, too, people with the fewest tangles improved most on CDR-SB. In the DIAN prevention trial, eight years of ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results