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We now understand that genomes in all three domains of life produce functional RNAs that do not encode proteins (non-coding (nc)RNAs), but do exert important influences on diverse cellular processes.

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The functional roles of small non-coding RNAs in vertebrates are beginning to be elucidated thanks to specific gene-deletion approaches. miR-15, miR-16 and miR-430 are involved in modulation of the ...